In the field of neurobiological research, positional genetics have been used to identify susceptibility genes which could be linked to the heritability of schizophrenia. In determining such, various strong and well-codified linkages have been identified. Genome-wide importance at P<0.05
Currently, though individual genes within some of the linked regions have been identified to be involved in replication. A higher weightage of the evidence found assists NRG1 and DTNBP1 as schizophrenia susceptibility loci.
In the midst of establishing further replications, identifying the part that each gene has to play, relationships with various phenotype aspects, as well as the likelihood of epistatic interactions from gene to gene and the interactions between gene products that are functional will require further research.
Therefore, identification of the existence of other linkages which suggests that there would be other susceptible genes linked to schizophrenia. This would aid researchers to gain a greater understanding about schizophrenia.
Sources:
Article: http://hmg.oxfordjournals.org/cgi/reprint/12/suppl_2/R125
Picture: http://blogs.psychologytoday.com/files/u81/Schizophrenia.jpg
Post by: Lim Keng Beng (41989658)
