Previously identifying the mechanism responsible for some forms of breast cancer has been quite imprecise leading to an inability in diagnosing the disease early on. However there has been a recent breakthrough in genetics that may change this. This discovery comes on the back of another recent finding which indicates tumor-suppressor genes are key in determining the mechanism that leads to uncontrolled cell proliferation – cancer. The breakthrough revolves around the p18 gene which, when mutated, overrides other genes and eventually leads to cancer.
The study was initiated when it was noted that p18 gene mutations were present in many cancer cells. Yue Xiong, senior study author stated, “When this gene is not expressed or is deleted, cells have no breaking mechanism. They will continue to grow and divide until they turn into cancer”.
300 people with breast cancer were tested for variations of the p18 gene and it was confirmed that a decreased expression of p18 correlates highly with the development of luminal tumors, those which form breast cancers. A mouse model has been developed to help researchers better understand the process involved and develop a treatment. “…Understanding this mechanism and having a good mouse model allows us to specifically test how treatments work against these tumors…” says Yue.It is hoped that with this discovery and a combination of new laboratory techniques will lead scientists to new treatment methods for luminal-type tumors and hopefully prevent or treat this type of breast cancer in the future.
Article source:
http://www.sciencedaily.com/releases/2009/05/090511164609.htm
