Study Findings Have Implications for Development of Pain-Relieving Drugs

Genetic variation in the OPRM1 receptor has been shown to cause people to respond differently to painkillers like morphine. Up to one third of people get substantial side effects from morphine. These effects include respiratory depression, and nausea and vomiting. This study showed many unknown variations of the gene that produces the primary biological target for these analgesics, the OPRM1 receptor.

Since there are such varied responses to morphine, this new research is important as it will allow doctors to provide patients with more effective pain relief. Morphine works on the receptors of the central nervous system and decreases the pain signals sent to the brain. The research will also lead to tests that can determine how effective morphine will be on an individual’s system.

Jim Martin

References:
http://www.newswise.com/articles/view/551405/
http://www.nda.ox.ac.uk/wfsa/html/u03/u03_016.htm