Shu-Chieh Hou(Paul)
41278464
The researchers in university of Buffallo has developed a nanometer substrate to against addiction of drug.Since .The new approach developed by the UB researchers also may be applicable to treating Parkinson's disease, cancer and a range of other neurologic and psychiatric disorders, which require certain drugs to be delivered to the brain.
DARPP-32 is a protein in the brain that facilitates addictive behaviors and plays a trigger role and cause the signal of addiction happen. Silencing of the DARPP-32 gene with certain kinds of ribonucleic acid (RNA), called short interfering RNA (siRNA), can inhibit production of this protein and thus, could help prevent drug addiction."The findings of this study tell us that these nanoparticles are both a safe and very efficient way of delivering to a variety of tissues highly sophisticated new drugs that turn off abnormal genes," said Stanley A. Schwartz, M.D.In fact, siRNA itself is not stable, so the researches combined it to rod-shaped nanometer particles which allow more siRNA to be loaded and more stabilizing and effectively for delivery to tissues(eg, brain)."We have demonstrated that we can use these gold nanorods to stabilize the siRNA molecules, take them across the blood-brain barrier and silence the gene," said Indrajit Roy, Ph.D.The researches successfully use RNA technique and nanotechnology to prevent the addiction of drug,which can be widely applied to the whole addiction range in future.
reference:
ScienceDaily(2009)To Fight Drug Addiction, Researchers Target The Brain With Nanoparticles (internet)http://www.sciencedaily.com/releases/2009/03/090324101747.htm
27/04/09 Assessed.
