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The article “Schizophrenia and Genetics: New Insights” published in the Current Psychiatry Reports in 2002 has found consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. The study found that several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes.
www.schizophrenia.com/schizpictures.htmlA genetic subtype of schizophrenia (22q deletion syndrome) has been identified and may serve as a model to study the etippathogensis of the disease. The 22q deletion syndrome is associated with a high rate of schizophrenia of up to 25% and is inherited in an autosomal dominant pattern. Diagnosis of 22qDS also has important genetic counseling implications which may, in the future, be available to patients. New evidence has also been found that spontaneous mutations may play a role in enhancing the illness.
en.wikipedia.org/wiki/22q11.2_deletion_syndromeIt is suggested from the progress to date that understanding the neurodevelopmental pathway from genetic susceptibility to schizophrenia will soon be fundamentally altered by molecular genetic advances in this complex disease.
Ethical issues have also been taken into consideration to determine the most appropriate implementation of services involving genetic testing for schizophrenia that will be made available to patients and their families in the future. These are guided by the experience gained in other neuropsychiatric disorders.
Gene discoveries are predicted to revolutionize medicine with the aid of The Human Genome Project. Such genetic advances will encompass psychiatry and lead to the identification of molecular subtypes of schizophrenia. And eventually an initial understanding of the pathogenesis of the disease will be followed.
Bibilographic details:Bassett, A. S., Chow, E. W., Weksberg, R., & Brzustowicz, L. (2002, August). Schizophrenia and Genetics: New Insights. Current Psychiatry Reports , Volume 4: Current Medicine Group LLC. Viewed via http://www.springerlink.com.ezproxy.library.uq.edu.au/content/v6128q50844448gx/fulltext.pdf
Ethical issues have also been taken into consideration to determine the most appropriate implementation of services involving genetic testing for schizophrenia that will be made available to patients and their families in the future. These are guided by the experience gained in other neuropsychiatric disorders.
Gene discoveries are predicted to revolutionize medicine with the aid of The Human Genome Project. Such genetic advances will encompass psychiatry and lead to the identification of molecular subtypes of schizophrenia. And eventually an initial understanding of the pathogenesis of the disease will be followed.
Bibilographic details:Bassett, A. S., Chow, E. W., Weksberg, R., & Brzustowicz, L. (2002, August). Schizophrenia and Genetics: New Insights. Current Psychiatry Reports , Volume 4: Current Medicine Group LLC. Viewed via http://www.springerlink.com.ezproxy.library.uq.edu.au/content/v6128q50844448gx/fulltext.pdf
