‘Master Regulator’ of Skin Formation Discovered

An online article has announced that researchers from Origan State University have discovered one gene in the human genome that controls the regulation of skin development. The gene is called CTIP2. Further knowledge compiled with better understanding of this gene could see major advances in addressing skin diseases and helping reduce the wrinkling of the skin.

Research on laboratory mice have shown that inadequate or loss of expression of gene CTIP2 leads to poor development in different levels of the skin and failure to synthesise a strong protective outer layer (see image above right; above, mice with CTIP2. Below, mice without CTIP2) Arup Indra, one of the University’s assistant professors of pharmacy said, "It also seems particularly important in lipid biosynthesis, which is relevant not only to certain skin diseases but also wrinkling and premature skin aging."

It is generally known that skin is the largest organ in the body but what isn’t so well documented is the fact that it is not static. It renews its surface every three or four weeks and it is when this renewing slows down that we begin to see wrinkles. So what causes the renewing to slow down? It is believed that some gene expression isn’t as effective later in life or when environmental factors adversely affect them and as a result, the genetic expression within cells slows. Stimulating this gene expression again in skin can be achieved by botanical extracts but knowledge of gene CTIP2 may allow us to achieve this stimulation more scientifically, successfully and permanently. This research project has obtained funding in the order of $1.5 million by the National Institutes of Health.

Sean Maxwell
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Source: http://www.sciencedaily.com/releases/2009/03/090324171608.htm