For a number of years, scientists have been investigating the correlation between an individual’s genetic makeup and their susceptibility to addition of various substances. It has been observed by researchers over the years that specific genome mutations in mice models do affect their tendency to become addicted to cocaine or to have a reduced reward result to morphine (Hanson, 2007). Carrying on from this research, Dr Li and Dr Burmeister at the University of Virginia Health System and the University of Michigan have done further research into the genetics behind multiple addictions.
While the general public often attribute multiple addictions of illicit substances to lower socioeconomic conditions, Li and Burmeister have discovered that many chromosomal peaks for addiction to alcohol, cannabis, cocaine, heroin, nicotine and opoids are situated in clusters along 11 chromosomes, often with overlaps. They hypothesis that an individual expressing a gene that promotes addiction in one of these identified clusters will in turn increase the individuals receptiveness to other dependences.
However, how the nature of gene variants and how they function is still unknown. A recommendation that has come from the study is that alleles of known addiction genes should be studied further to determine their affect. When this is understood, scientists will be one step closer to being able to develop effective personal therapies for addicts.
[A summary of the locations of chromosomal peaks for addiction to alcohol, cannabis, cocaine, heroin, nicotine and opoids . Sourced from http://www.sciencedaily.com/releases/2009/03/090310142912.htm ]
Sources:
University of Virginia Health System (2009, March 16). Common Genes Tied To Alcohol, Nicotine, Cocaine Addictions. ScienceDaily. Retrieved March 16, 2009, from http://www.sciencedaily.com /releases/2009/03/090310142912.htm
Hanson, G. (2007). Genetics is an Important Factor in Addiction. Retrieved March 16, 2009, from The University of Utah: http://learn.genetics.utah.edu/content/addiction/genetics/
