06 June 2009

Mutation in filaggrin gene trigger allergies



Eczema can cause the skin to become very red and itchy


Breakthrough of genetic defect in mice enable scientist to identify what factor is responsible for the rapid increase in allergic today.
Scientists in Dundee, Ireland and Japan discover the filaggrin defect in mice which causes allergic inflammation , similarly like what happen in human eczema.They found out that the filaggrin gene is very important since this gene enable skin to produce protective barrier.So, this will block the allergens from entering the body,thus preventing allergic formation.

Scientist pointed out that about one in five children in Britain and other westernised nations suffer from eczema.
Eczema cause irritating patch of sore skin,while in extreme cases ,extensive areas may become inflamed and unbearably itchy. So, the children with this condition are very susceptible to get allergic conditions, like asthma , fever and

The finding indicates that many cases of eczema are induced by genetic mutation in filaggrin gene.

The breakthrough of genetic defect of filaggrin gene enable enable scientist to develop therapies for eczema and other allergies by suppressing the defective filaggrin gene.Now, scientists are still looking for the drugs or treatments that aim at the filaggrin gene and hopefully they will find the cure for these disease in recent time.


REFERENCE…
Mouse Gene Aids Allergy Research 2009, BBC News, 6 April, viewed 28 May 2009 at


Link to original source of article…
http://news.bbc.co.uk/2/hi/uk_news/scotland/tayside_and_central/7985307.stm

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